Simon Achikgyozyan was born in Galats, in 1939. His father, Hovhannes survived the genocide against Armenians.

In 1946, Simon and his family were repatriated to Soviet Armenia. He studied at Yerevan Secondary School No. 24. In 1955 he entered the Faculty of Geology of Yerevan State University, graduating in 1960 with a degree in engineering-geology. Ս. Achikgyozyan defended his dissertation in Moscow in 1970. He was awarded the title of senior researcher in 1984. In 1960-1991 he worked at the Institute of Geological Sciences of the Academy of Sciences of the Armenian SSR, authored more than 70 scientific works, engaged in translations. He has been lecturing at Yerevan State University for about 11 years.

He sang in the “Narek” male choir in Khor Virap monastery for many years.

S. Achikgyozyan was elected a member of the Foreign Relations Committee at the first congress of the Armenian National Movement in 1989. The same year he joined the “Arabo” volunteer detachment, took part in the self-defense battles of Gnishik, Yeraskh, Areni, Khachik in Yeghegnadzor region, Voskepar in Noyemberyan and other border villages, then left for Artsakh (Shahumyan region), assuming the command of the detachment of “Arabo” in Martunashen on April 19, 1991. 

He died on April 30, 1991 during the self-defense of Martunashen, while preventing the “Ring” operation carried out by the Azerbaijani Special Forces (OMON) with the support of the forces of the USSR Ministry of Internal Affairs. His body is buried in the cemetery of Kanaker-Zeytun administrative district of Yerevan.

By the decree of the President of the Republic of Armenia NH-640 of September 20, 1996, S. Achikgyozyan was posthumously awarded the “Combat Cross” order of the 1st degree.